' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.9
USERS' SCORE
Excellent
Based on 3 Reviews
9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%**
Saturated Fat
< 0.5 g
2%**
Polyunsaturated Fat
0.5 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Omega-3 Fatty Acids:
Eicosapentaenoic Acid (EPA)
180 mg
†
Docosahexaenoic Acid (DHA)
120 mg
†
Top Medical Research Studies
9.5
Eicosapentaenoic acid benefits CFS
Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes.
High relevance to CFS treatment
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
Read More
9
Eicosapentaenoic acid shows promise
The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome.
Highly relevant to the study focus
We examined the link between chronic fatigue syndrome (CFS) and essential fatty acids, focusing specifically on eicosapentaenoic acid (EPA). This investigation arose from various studies highlighting the potential role essential fatty acids play in alleviating symptoms associated with CFS.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
Read More
4
Omega-3 fatty acids' role in CFS
In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.
Moderate relevance; highlights omega-3
We examined the impact of omega-3 polyunsaturated fatty acids, particularly eicosapentaenoic acid (EPA), on chronic fatigue syndrome (CFS). Our research included 22 CFS patients and 12 healthy controls, where we measured serum levels of these fatty acids using advanced techniques.
Our findings revealed that CFS patients had elevated levels of omega-6 fatty acids while showing significantly lower ratios of omega-3 to omega-6. This imbalance was closely linked to the severity of CFS symptoms like fatigue and memory issues. We also found interesting connections between lower omega-3 levels and reduced serum zinc, hinting at immune system challenges present in CFS.
Notably, the study suggests that a decrease in omega-3 fatty acids could influence the immune response in those suffering from CFS. This outcome opens avenues for potential treatment strategies using omega-3 supplements like EPA. However, we did not have direct evidence of treatment outcomes, so while the results are promising, further investigation is needed to clarify how effective eicosapentaenoic acid might be as a treatment for CFS.
Our findings revealed that CFS patients had elevated levels of omega-6 fatty acids while showing significantly lower ratios of omega-3 to omega-6. This imbalance was closely linked to the severity of CFS symptoms like fatigue and memory issues. We also found interesting connections between lower omega-3 levels and reduced serum zinc, hinting at immune system challenges present in CFS.
Notably, the study suggests that a decrease in omega-3 fatty acids could influence the immune response in those suffering from CFS. This outcome opens avenues for potential treatment strategies using omega-3 supplements like EPA. However, we did not have direct evidence of treatment outcomes, so while the results are promising, further investigation is needed to clarify how effective eicosapentaenoic acid might be as a treatment for CFS.
Read More
Most Useful Reviews
9.5
Relief from fatigue
This product is excellent for those suffering from joint pain and chronic fatigue syndrome. I recommend being honest, as I noticed results from my first week of use.
Read More
8.8
Improved sleep quality
Good according to my friend Tony, I started encouraging him to take Zain Samak as it is beneficial for improving my health, particularly my sleep and the chronic fatigue syndrome I experience at 46. These gelatin capsules are easy to swallow and odourless. They help reduce cholesterol, benefit heart health, and strengthen immunity.
Read More
8.8
Effective skin treatment
This fish oil has effectively reduced inflammatory responses linked to my chronic fatigue syndrome. After long-term use of medication for chronic measles without improvement, I find this tasteless oil easy to swallow and it has significantly resolved my skin issues. Taking it daily has reduced the likelihood of a relapse.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.9
9.5
Eicosapentaenoic acid benefits CFS
Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes.
High relevance to CFS treatment
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
Read More
9
Eicosapentaenoic acid shows promise
The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome.
Highly relevant to the study focus
We examined the link between chronic fatigue syndrome (CFS) and essential fatty acids, focusing specifically on eicosapentaenoic acid (EPA). This investigation arose from various studies highlighting the potential role essential fatty acids play in alleviating symptoms associated with CFS.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
Read More
9
Effective treatment for fatigue syndrome
Effect of high doses of essential fatty acids on the postviral fatigue syndrome.
Assessing EPA's role in fatigue
We conducted a thorough investigation into the effects of essential fatty acids, including eicosapentaenoic acid (EPA), on individuals suffering from postviral fatigue syndrome. In a well-structured trial, 63 adults with this condition participated in a double-blind, placebo-controlled study. They had been living with severe fatigue and other troubling symptoms for one to three years following a viral infection.
Patients received either an active treatment containing EPA and other essential fatty acids or a placebo for three months. Their overall health, fatigue levels, and other symptoms were assessed at the beginning, after one month, and at the end of the study. Strikingly, we observed that 74% of those taking the essential fatty acids reported improvements after one month, rising to 85% after three months. In contrast, only 23% and 17% of the placebo group noted any benefit at those respective time points.
Notably, the fatty acid levels in the participants' red blood cells, which were abnormal at the beginning of the trial, showed significant improvement with the active treatment. Importantly, we found no adverse side effects from the treatment, leading us to conclude that essential fatty acids can be a safe and effective option for people dealing with postviral fatigue syndrome.
Patients received either an active treatment containing EPA and other essential fatty acids or a placebo for three months. Their overall health, fatigue levels, and other symptoms were assessed at the beginning, after one month, and at the end of the study. Strikingly, we observed that 74% of those taking the essential fatty acids reported improvements after one month, rising to 85% after three months. In contrast, only 23% and 17% of the placebo group noted any benefit at those respective time points.
Notably, the fatty acid levels in the participants' red blood cells, which were abnormal at the beginning of the trial, showed significant improvement with the active treatment. Importantly, we found no adverse side effects from the treatment, leading us to conclude that essential fatty acids can be a safe and effective option for people dealing with postviral fatigue syndrome.
Read More
9
Essential fatty acids aid fatigue syndrome
Effect of high doses of essential fatty acids on the postviral fatigue syndrome.
Study shows DHA's potential benefit
We conducted a study to evaluate the effectiveness of essential fatty acids, particularly docosahexaenoic acid (DHA), in treating postviral fatigue syndrome, which affects many individuals after a viral infection.
In a double-blind, placebo-controlled setup involving 63 adults, we administered a mixture of essential fatty acids to half of the participants while the other half received a placebo. Each person received eight capsules daily for three months, and we checked their overall condition, fatigue, and other symptoms at various points throughout the study.
Excitingly, we observed significant improvements among those taking the active treatment. After just one month, 74% of participants in the DHA group felt better compared to only 23% in the placebo group. That number rose to 85% at the three-month mark, indicating that while the placebo group reverted to their initial state, those receiving essential fatty acids continued to improve.
Additionally, we saw that the fatty acid levels in patients’ blood cells normalized with treatment, and there were no adverse effects reported. Overall, our findings suggest that DHA, as part of a broader essential fatty acid approach, is a safe and beneficial option for those suffering from postviral fatigue syndrome.
In a double-blind, placebo-controlled setup involving 63 adults, we administered a mixture of essential fatty acids to half of the participants while the other half received a placebo. Each person received eight capsules daily for three months, and we checked their overall condition, fatigue, and other symptoms at various points throughout the study.
Excitingly, we observed significant improvements among those taking the active treatment. After just one month, 74% of participants in the DHA group felt better compared to only 23% in the placebo group. That number rose to 85% at the three-month mark, indicating that while the placebo group reverted to their initial state, those receiving essential fatty acids continued to improve.
Additionally, we saw that the fatty acid levels in patients’ blood cells normalized with treatment, and there were no adverse effects reported. Overall, our findings suggest that DHA, as part of a broader essential fatty acid approach, is a safe and beneficial option for those suffering from postviral fatigue syndrome.
Read More
8
Eicosapentaenoic acid's potential in CFS
Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome).
Moderate relevance to treatment exploration
We explored the connection between eicosapentaenoic acid (EPA) and chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis. The research indicates that individuals suffering from CFS may experience complications linked to persistent viral infections, which could hinder their body's ability to produce necessary fatty acids.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 3 Reviews
9
9.5
Relief from fatigue
This product is excellent for those suffering from joint pain and chronic fatigue syndrome. I recommend being honest, as I noticed results from my first week of use.
8.8
Improved sleep quality
Good according to my friend Tony, I started encouraging him to take Zain Samak as it is beneficial for improving my health, particularly my sleep and the chronic fatigue syndrome I experience at 46. These gelatin capsules are easy to swallow and odourless. They help reduce cholesterol, benefit heart health, and strengthen immunity.
Read More
8.8
Effective skin treatment
This fish oil has effectively reduced inflammatory responses linked to my chronic fatigue syndrome. After long-term use of medication for chronic measles without improvement, I find this tasteless oil easy to swallow and it has significantly resolved my skin issues. Taking it daily has reduced the likelihood of a relapse.
Read More
